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Published January 23, 2026 ©

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WIZnet Serial-to-Ethernet Module Selection Guide

WIZnet serial-to-Ethernet modules: 9 models with 4 serial ports, encryption, Modbus, dual Ethernet. For industrial/IoT applications.

COMPONENTS
PROJECT DESCRIPTION

Preface

This article focuses on WIZnet's 8 core serial-to-Ethernet modules (WIZS2E-R02, W7500S2E-R1, W7500S2E-S1, W7500S2E-D1, W5500S2E-S1, W5500S2E-R1, WIZ750SR, WIZ750SR-110, WIZ510SR-RP). Each model has its own emphasis on serial port specifications, network performance, security configurations, and compatibility, covering full-scenario requirements from industrial-grade stable networking to encrypted transmission. They meet diverse design needs from embedded lightweight devices to industrial precision terminals, helping users quickly identify suitable solutions and reduce selection and development costs.

Core Features of Each Module

WIZS2E-R02

ARM Cortex-M3 + TCP/IP + MAC + PHY architecture

Maximum baud rate: 3000bps ~ 1.152Mbps, 4 serial ports

Applications: Industrial serial port servers, multi-channel serial-to-Ethernet gateways

W7500S2E-R1

ARM Cortex-M0 + TCP/IP + MAC + PHY architecture

Integrated RJ45 port, meets basic Ethernet data transmission needs

Applications: Industrial sensor gateways, PLC serial-to-Ethernet conversion, small-to-medium automation equipment networking

W7500S2E-S1

Industrial operating temperature, integrated network transformer

Supports AT commands, web configuration, and PC software configuration for quick Ethernet access

Applications: Building security terminals, batch-produced low-cost networking devices

W7500S2E-D1

Dual Ethernet port design, industrial wide temperature range, supports CTS/RTS flow control

Supports AT commands, PC software, and web configuration, supports local firmware upgrade

Applications: Dual-network redundant industrial gateways, precision instrument dual-path networking, high-reliability data acquisition terminals

W5500S2E-S1

W5500+STM32F103 architecture, maximum baud rate 1.152Mbps

Supports full Modbus protocol conversion. Features password authentication and remote firmware upgrade, suitable for complex industrial scenarios

Applications: Industrial Modbus gateways, high-speed serial device networking, multi-protocol conversion terminals

W5500S2E-R1

Hardware TCP/IP protocol stack, RJ-45 interface, supports CTS/RTS flow control

Transparent/AT dual mode, supports remote configuration and keep-alive function, 3.3V power supply

Applications: Industrial automation measurement and control equipment, networking modules for high-temperature/high-humidity environments, multi-parameter serial device to Ethernet conversion

WIZ750SR

Three serial port versions available (TTL/RS232/RS485)

Industrial-grade components, built-in ESD protection

Applications: Industrial field multi-serial terminals, networking in harsh environments

WIZ750SR-110

Supports virtual serial port and multiple configuration methods, compact size suitable for rack installation

TTL / RS232 x 1 selectable

Applications: Traditional RS232 device conversion to Ethernet, centralized management of data center serial devices, industrial control terminal expansion

WIZ510SR-RP

RP2040+W5100S architecture, supports SSL/TLS encryption and MQTT(S) protocol

Independent debug UART, built-in ESD protection, operating temperature -20℃ to 85℃

Applications: IoT encrypted cloud gateways, sensitive data transmission devices, low-power smart monitoring terminals

Quick Selection Guide

Decision DimensionCriteriaRecommended Models
Serial SpeedNeed high baud rate?WIZS2E-R02, W5500S2E-S1, W5500S2E-R1
Security NeedsNeed encryption protocols (SSL/MQTT(S))?WIZ510SR-RP
Multiple PortsNeed dual Ethernet ports?W7500S2E-D1
Protocol NeedsNeed full Modbus protocol conversion?WIZS2E-R02, W5500S2E-S1, W5500S2E-R1, WIZ510SR-RP
Multiple Serial PortsNeed multiple serial ports?WIZS2E-R02
Serial SpecificationNeed other serial specifications (RS485/RS232)?WIZ750SR, WIZ750SR-110, WIZ510SR-RP

Core Parameters & Feature Comparison Table

ModelCore ConfigurationKey FeaturesTypical Applications
WIZS2E-R02ARM Cortex-M3 + TCP/IP + MAC + PHY architectureMulti-port high-speed serialIndustrial serial servers, multi-channel serial-to-Ethernet gateways
W7500S2E-R1W7500 chip + RJ45 portQuick Ethernet access, multiple configuration methodsIndustrial sensor gateways, PLC conversion to Ethernet
W7500S2E-S1Compact size with integrated network transformerDual transmission modes, keep-alive functionCivilian smart controllers, batch-produced devices
W7500S2E-D1Dual Ethernet ports, CTS/RTS flow controlWide-temperature industrial grade, firmware upgradeDual-network redundant gateways, precision instruments
W5500S2E-S1W5500+STM32, 1.152MbpsFull Modbus protocol, remote upgradeIndustrial Modbus gateways, high-speed devices
W5500S2E-R1RJ-45 interface, supports CTS/RTS flow controlMultiple configuration methods, high baud rateIndustrial measurement and control equipment, complex environments
WIZ750SRMultiple serial port versions, ESD protectionRS485/RS232/TTL serial specifications selectableLegacy equipment upgrades, industrial multi-serial terminals
WIZ750SR-110Supports virtual serial port and multiple configuration methodsVirtual serial port, rack-mountableTraditional RS232 devices, data center management
WIZ510SR-RPRP2040+W5100S, SSL/TLSMQTT(S), independent debug portEncrypted cloud gateways, sensitive data transmission

Common Selection Q&A

Q1: What are the core application scenarios for wide-temperature design?
A1: -40℃ to 85℃ wide-temperature range is suitable for extreme environments such as industrial sites, outdoor equipment, and high-temperature data centers, preventing communication interruptions caused by temperature fluctuations.

Q2: What are the advantages of the three configuration methods (tool/web/AT)?
A2: Tool configuration is suitable for batch debugging, web configuration supports remote management, and AT command configuration is suitable for embedded motherboard integration. These three methods provide full coverage to meet different scenarios such as production line manufacturing, on-site maintenance, and secondary development, enhancing usage flexibility.

Q3: Is it necessary to choose modules with Modbus protocol conversion?
A3: Choosing modules with Modbus protocol conversion functionality enables direct Ethernet access and cloud monitoring for traditional Modbus RTU/ASCII devices, eliminating additional gateway costs and simplifying industrial networking processes.

Q4: What scenarios are encryption protocols (SSL/MQTT(S)) suitable for?
A4: Encryption protocols are suitable for public network transmission and scenarios involving sensitive data such as finance, healthcare, and security, preventing data theft and tampering.

Typical Application Case References

WIZS2E-R02: Industrial serial port servers, multi-channel serial-to-Ethernet gateways (multi-port high-speed serial)

W7500S2E-R1: Industrial sensor gateways (ARM Cortex-M0 architecture + RJ45 port + serial-to-Ethernet, suitable for automation equipment networking)

W7500S2E-S1: Building security terminals (industrial wide temperature + network transformer + multiple configuration methods, low-cost batch networking)

W7500S2E-D1: Dual-network redundant industrial gateways (dual Ethernet ports + wide temperature + flow control + flexible configuration, high-reliability data acquisition)

W5500S2E-S1: Industrial Modbus gateways (W5500+STM32F103 architecture + full protocol conversion + encrypted upgrade, suitable for complex scenarios)

W5500S2E-R1: Industrial measurement and control equipment modules (hardware TCP/IP protocol stack + flow control + dual mode, suitable for high-temperature/high-humidity environments)

WIZ750SR: Industrial multi-serial terminals (multiple serial port versions + ESD protection + industrial-grade components, legacy equipment upgrades in harsh environments)

WIZ750SR-110: Data center serial device managers (virtual serial port + compact size + selectable interfaces, centralized expansion)

WIZ510SR-RP: IoT encrypted cloud gateways (RP2040+W5100S architecture + SSL/TLS encryption + ESD protection, sensitive data transmission)

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