---
title: "WIZnet Serial-to-Ethernet Module Selection Guide"
url: "https://maker.wiznet.io/ronpang/projects/wiznet-serial-to-ethernet-module-selection-guide/"
markdown_url: "https://maker.wiznet.io/ronpang/projects/wiznet-serial-to-ethernet-module-selection-guide/md"
type: "WCC: WIZnet Created Content"
author: "ronpang"
author_url: "https://maker.wiznet.io/ronpang/"
published: "2026-01-23"
language: "en"
likes: 0
views: 1297
comments: 0
source: "WIZnet Makers (https://maker.wiznet.io/)"
---

# WIZnet Serial-to-Ethernet Module Selection Guide

> WIZnet serial-to-Ethernet modules: 9 models with 4 serial ports, encryption, Modbus, dual Ethernet. For industrial/IoT applications.

## Article

## Preface

This article focuses on WIZnet's 8 core serial-to-Ethernet modules (WIZS2E-R02, W7500S2E-R1, W7500S2E-S1, W7500S2E-D1, W5500S2E-S1, W5500S2E-R1, WIZ750SR, WIZ750SR-110, WIZ510SR-RP). Each model has its own emphasis on serial port specifications, network performance, security configurations, and compatibility, covering full-scenario requirements from industrial-grade stable networking to encrypted transmission. They meet diverse design needs from embedded lightweight devices to industrial precision terminals, helping users quickly identify suitable solutions and reduce selection and development costs.

![](https://maker.wiznet.io/upload/ckeditor5/419353359%5F1769192317%2Epng)

## Core Features of Each Module

### WIZS2E-R02

ARM Cortex-M3 + TCP/IP + MAC + PHY architecture

Maximum baud rate: 3000bps ~ 1.152Mbps, 4 serial ports

**Applications**: Industrial serial port servers, multi-channel serial-to-Ethernet gateways

### W7500S2E-R1

ARM Cortex-M0 + TCP/IP + MAC + PHY architecture

Integrated RJ45 port, meets basic Ethernet data transmission needs

**Applications**: Industrial sensor gateways, PLC serial-to-Ethernet conversion, small-to-medium automation equipment networking

### W7500S2E-S1

Industrial operating temperature, integrated network transformer

Supports AT commands, web configuration, and PC software configuration for quick Ethernet access

**Applications**: Building security terminals, batch-produced low-cost networking devices

### W7500S2E-D1

Dual Ethernet port design, industrial wide temperature range, supports CTS/RTS flow control

Supports AT commands, PC software, and web configuration, supports local firmware upgrade

**Applications**: Dual-network redundant industrial gateways, precision instrument dual-path networking, high-reliability data acquisition terminals

### W5500S2E-S1

W5500+STM32F103 architecture, maximum baud rate 1.152Mbps

Supports full Modbus protocol conversion. Features password authentication and remote firmware upgrade, suitable for complex industrial scenarios

**Applications**: Industrial Modbus gateways, high-speed serial device networking, multi-protocol conversion terminals

### W5500S2E-R1

Hardware TCP/IP protocol stack, RJ-45 interface, supports CTS/RTS flow control

Transparent/AT dual mode, supports remote configuration and keep-alive function, 3.3V power supply

**Applications**: Industrial automation measurement and control equipment, networking modules for high-temperature/high-humidity environments, multi-parameter serial device to Ethernet conversion

### WIZ750SR

Three serial port versions available (TTL/RS232/RS485)

Industrial-grade components, built-in ESD protection

**Applications**: Industrial field multi-serial terminals, networking in harsh environments

### WIZ750SR-110

Supports virtual serial port and multiple configuration methods, compact size suitable for rack installation

TTL / RS232 x 1 selectable

**Applications**: Traditional RS232 device conversion to Ethernet, centralized management of data center serial devices, industrial control terminal expansion

### WIZ510SR-RP

RP2040+W5100S architecture, supports SSL/TLS encryption and MQTT(S) protocol

Independent debug UART, built-in ESD protection, operating temperature -20℃ to 85℃

**Applications**: IoT encrypted cloud gateways, sensitive data transmission devices, low-power smart monitoring terminals

## Quick Selection Guide

| Decision Dimension | Criteria | Recommended Models |
| --- | --- | --- |
| **Serial Speed** | Need high baud rate? | WIZS2E-R02, W5500S2E-S1, W5500S2E-R1 |
| **Security Needs** | Need encryption protocols (SSL/MQTT(S))? | WIZ510SR-RP |
| **Multiple Ports** | Need dual Ethernet ports? | W7500S2E-D1 |
| **Protocol Needs** | Need full Modbus protocol conversion? | WIZS2E-R02, W5500S2E-S1, W5500S2E-R1, WIZ510SR-RP |
| **Multiple Serial Ports** | Need multiple serial ports? | WIZS2E-R02 |
| **Serial Specification** | Need other serial specifications (RS485/RS232)? | WIZ750SR, WIZ750SR-110, WIZ510SR-RP |

## Core Parameters & Feature Comparison Table

| **Model** | **Core Configuration** | **Key Features** | **Typical Applications** |
| --- | --- | --- | --- |
| WIZS2E-R02 | ARM Cortex-M3 + TCP/IP + MAC + PHY architecture | Multi-port high-speed serial | Industrial serial servers, multi-channel serial-to-Ethernet gateways |
| W7500S2E-R1 | W7500 chip + RJ45 port | Quick Ethernet access, multiple configuration methods | Industrial sensor gateways, PLC conversion to Ethernet |
| W7500S2E-S1 | Compact size with integrated network transformer | Dual transmission modes, keep-alive function | Civilian smart controllers, batch-produced devices |
| W7500S2E-D1 | Dual Ethernet ports, CTS/RTS flow control | Wide-temperature industrial grade, firmware upgrade | Dual-network redundant gateways, precision instruments |
| W5500S2E-S1 | W5500+STM32, 1.152Mbps | Full Modbus protocol, remote upgrade | Industrial Modbus gateways, high-speed devices |
| W5500S2E-R1 | RJ-45 interface, supports CTS/RTS flow control | Multiple configuration methods, high baud rate | Industrial measurement and control equipment, complex environments |
| WIZ750SR | Multiple serial port versions, ESD protection | RS485/RS232/TTL serial specifications selectable | Legacy equipment upgrades, industrial multi-serial terminals |
| WIZ750SR-110 | Supports virtual serial port and multiple configuration methods | Virtual serial port, rack-mountable | Traditional RS232 devices, data center management |
| WIZ510SR-RP | RP2040+W5100S, SSL/TLS | MQTT(S), independent debug port | Encrypted cloud gateways, sensitive data transmission |

## Common Selection Q&A

**Q1: What are the core application scenarios for wide-temperature design?A1:** -40℃ to 85℃ wide-temperature range is suitable for extreme environments such as industrial sites, outdoor equipment, and high-temperature data centers, preventing communication interruptions caused by temperature fluctuations.

**Q2: What are the advantages of the three configuration methods (tool/web/AT)?A2:** Tool configuration is suitable for batch debugging, web configuration supports remote management, and AT command configuration is suitable for embedded motherboard integration. These three methods provide full coverage to meet different scenarios such as production line manufacturing, on-site maintenance, and secondary development, enhancing usage flexibility.

**Q3: Is it necessary to choose modules with Modbus protocol conversion?A3:** Choosing modules with Modbus protocol conversion functionality enables direct Ethernet access and cloud monitoring for traditional Modbus RTU/ASCII devices, eliminating additional gateway costs and simplifying industrial networking processes.

**Q4: What scenarios are encryption protocols (SSL/MQTT(S)) suitable for?A4:** Encryption protocols are suitable for public network transmission and scenarios involving sensitive data such as finance, healthcare, and security, preventing data theft and tampering.

## Typical Application Case References

**WIZS2E-R02**: Industrial serial port servers, multi-channel serial-to-Ethernet gateways (multi-port high-speed serial)

**W7500S2E-R1**: Industrial sensor gateways (ARM Cortex-M0 architecture + RJ45 port + serial-to-Ethernet, suitable for automation equipment networking)

**W7500S2E-S1**: Building security terminals (industrial wide temperature + network transformer + multiple configuration methods, low-cost batch networking)

**W7500S2E-D1**: Dual-network redundant industrial gateways (dual Ethernet ports + wide temperature + flow control + flexible configuration, high-reliability data acquisition)

**W5500S2E-S1**: Industrial Modbus gateways (W5500+STM32F103 architecture + full protocol conversion + encrypted upgrade, suitable for complex scenarios)

**W5500S2E-R1**: Industrial measurement and control equipment modules (hardware TCP/IP protocol stack + flow control + dual mode, suitable for high-temperature/high-humidity environments)

**WIZ750SR**: Industrial multi-serial terminals (multiple serial port versions + ESD protection + industrial-grade components, legacy equipment upgrades in harsh environments)

**WIZ750SR-110**: Data center serial device managers (virtual serial port + compact size + selectable interfaces, centralized expansion)

**WIZ510SR-RP**: IoT encrypted cloud gateways (RP2040+W5100S architecture + SSL/TLS encryption + ESD protection, sensitive data transmission)

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Source: https://maker.wiznet.io/ronpang/projects/wiznet-serial-to-ethernet-module-selection-guide/